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Molecular weight: 320,000 Da (secretory) H-chain type (MW): alpha (55,000 Da) Serum concentration: 1 to 4 mg/mL; Percent of total immunoglobulin: 15%; Glycosylation (by weight): 10%; Distribution: intravascular and secretions; Function: protect mucus membranes; Learn more about IgA
- IGE
Properties of IgE: Molecular weight: 200,000; H-chain type...
- Introduction to Immunoglobulins
IgG and IgA are further grouped into subclasses (e.g., in...
- Immunoglobulin IgG Class
IgG4. Comprising usually less than 4% of total IgG, IgG4...
- Antibody Isotyping and Characterization
Antibody titer is an assay-specific measurement. One...
- Introduction to Antibody Production & Purification
Antibody purification involves isolation of antibody from...
- Immunoglobulin IgA Class
IgA is a very weak complement-activating antibody; hence, it...
- Immunoglobulin IgM Class
IgM can recognize epitopes on invading microorganisms,...
- Antibody-binding Proteins
Protein A is generally preferred for rabbit, pig, dog and...
- IGE
The approximate molecular weight of an IgG antibody is 150 kDa. IgG antibodies have 4 isotypes – IgG1, IgG2, IgG3 and IgG4. GenScript Production Scientists have the experience in producing a variety of IgG isotypes including human IgG1, human IgG4 and mouse IgG1.
chains of molecular weight -25000. The molecular weight of IgG is thus typically approximately 150000. The light chains are solely associated with the Fab arms of the molecule whereas the heavy chains span Fab and Fc parts. A single disulphide bond connects heavy and light chains as shown in Figure 1.2a.
The IgG antibody molecule is made up of four polypeptide chains, comprising two identical light chains and two identical heavy chains, and can be thought of as forming a flexible Y-shaped structure.
23 sty 2024 · IgG1 comprises 60 to 65% of the total main subclass of IgG and is usually produced in response to protein antigens which are T-dependent antigens. The molecular weight of IgG1 is 150kDa. The IgG1 are particularly good opsonins and mediators of ADCC because FcγRs bind sIgG1 antibodies with high affinity.
IgG antibodies are large globular proteins made of four peptide chains; [6] two identical γ (gamma) heavy chains of about 50 kDa and two identical light chains of about 25 kDa. The resulting tetrameric quaternary structure, therefore, has a total molecular weight of about 150 kDa. [7] .
8 wrz 2020 · IgG is a monomer with an approximate molecular weight of 146 Kd and a serum concentration of 9.0 mg/mL. IgG is said to be divalent, i.e., it has two identical antigen-binding sites that comprise 2 L chains and 2 H chains joined by disulfide bonds.
