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Intracerebroventricular injection (often abbreviated as ICV injection) is a route of administration for drugs via injection into the cerebral ventricles so that it reaches the cerebrospinal fluid (CSF).
3 paź 2011 · In this video, we demonstrate the step-by step procedures involving two types of injection strategies that can be used to target the CNS: 1) direct injection into the CNS utilizing intracerebroventricular (ICV) injection; or 2) IV injection targeting the temporal/facial vein.
1 lip 2018 · A recent comprehensive literature review on the clinical use and complications of ICV drug delivery revealed that device-associated complication rates are variable, and may be as high as 33% for non-infectious complications and 27% for infectious complications.
15 wrz 2017 · Because of the larger volume of post-injection dilution, chemically induced arachnoiditis and meningitis are less likely to occur when drugs are administered by the ICV route rather than by the lumbar route.
Adverse effects of ICV opioids include nausea, drowsiness, somnolence and mental clouding, visual hallucinations, miosis, headache, dizziness, pruritis, diaphoresis, urinary retention, and constipation.
1 maj 2018 · Adverse effects of ICV drug administration include potential neurosurgical complications, such as intracranial hemorrhage and infections, device misplacement or malfunctioning, CSF leakage, and...
In all publications reporting long-term use of ICV access devices (in situ median 30 weeks), patients had the device implanted for one to 7156 days per device and experienced two to 280 punctures per device. Table 1 presents the duration of ICV access device use and device presence across studies.
