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10 maj 2021 · Animals were treated by either direct intracerebroventricular (ICV) injection, by intrathecal (IT) infusion into the cerebrospinal fluid, or by intranasal (IN) instillation of AAV9-IDUA vector. AAV9-IDUA was administered to IDUA-deficient mice that were either immunosuppressed with cyclophosphamide (CP), or immunotolerized at birth by weekly ...
3 paź 2011 · In this video, we demonstrate the step-by step procedures involving two types of injection strategies that can be used to target the CNS: 1) direct injection into the CNS utilizing intracerebroventricular (ICV) injection; or 2) IV injection targeting the temporal/facial vein.
Examples include the treatment of Spinal Muscular Atrophy (SMA), the administration of chemotherapy in gliomas, and the administration of drugs for long-term pain management. ICV injection is also used in the creation of diseased animal models specifically to model neurological disorders.
This opinion outlines principal technical aspects of direct CNS delivery via intracerebroventricular (ICV) or intrathecal (IT) injection to common nonclinical test species (rodents, dogs, and nonhuman primates) and describes procedure-related clinical and histopathological effects that confound interpretation of test article-related effects.
The ICV route of administration is an established and globally used method of drug delivery; individual clinics' procedures and recommended guidelines on the use of ICV access devices (e.g., Ommaya and Rickham reservoirs) have been published (summarized in Fig 2). 27,43,44 Numerous studies have demonstrated that employing strict aseptic ...
1 lip 2018 · A recently approved treatment for CLN2 disease (neuronal ceroid lipofuscinosis type 2) utilizes the ICV route via a slow infusion (2.5 mL/ h) using a Huber non-coring needle and syringe pump, with post-infusion flushing of the line to ensure complete dosing [23].
Rabies vaccine is given to persons who have been exposed (eg, by a bite, scratch, or lick) to an animal that is known, or thought, to have rabies. This is called post-exposure prophylaxis. Rabies vaccine may also be given ahead of time to persons who have a high risk of getting infected with rabies virus.
