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28 lut 2019 · The structure of the extracellular domains of human interleukin 11 alpha receptor reveals mechanisms of cytokine engagement. Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-11Rα, and the β-subunit receptor, gp130.
Introduction. Cell-Chromosome-DNA. What’s So Special About DNA? DNA is one of the most boring macromolecules imaginable - its made of only four building blocks and has a perfectly monotonous structure. Worse yet, DNA just sits there - it doesn’t catalyze reactions or build the cell or organism. So, what’s. so. good. about. DNA?
29 sie 2013 · The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6. (2014) Acta Crystallogr D Biol Crystallogr 70: 2277-2285. Interleukin (IL)-11 is a multifunctional member of the IL-6 family of cytokines.
7 mar 2024 · Here we solve the cryoEM structure of the IL-11 receptor recognition complex to discover how differences in gp130-binding interfaces may drive signalling outcomes.
1 cze 1997 · The 5′-flanking region of the human IL-11 gene contains several DNA motifs postulated to be involved in transcriptional control.
We reported the first crystal structure of IL-11 in 2014 (98) and have recently reported a higher-resolution structure of the cytokine (Figure 6A) (174). Our structures show that IL-11...
The basic structure of DNA provides insight into its function. The main features of its structure are that it can reliably: (1) reproduce exact copies of this information to pass on to descendant cells, and (2) use the information to create proteins that produce and regulate the biochemistry of the cell.
