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The pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt or HMP shunt) is a metabolic pathway parallel to glycolysis. [1] It generates NADPH and pentoses (five-carbon sugars) as well as ribose 5-phosphate, a precursor for the synthesis of nucleotides. [1]
1 maj 2023 · The HMP shunt is an alternative pathway to glycolysis and is used to produce ribose-5-phosphate and nicotinamide adenine dinucleotide phosphate (NADPH). This pathway occurs in the oxidative and non-oxidative phases, each comprising a series of reactions.
RESUME JURNAL HMP SHUNT Jalur Pentosa Fosfat (Hexosa Monophosphat Shunt = HMS) merupakan suatu lintasan alternatif dari metabolisme glukose. Jalur ini tidak menghasilkan ATP, tetapi mempunyai 2 peran penting: 1. menghasilkan NADPH yang diperlukan pada sintesis reduktif, misalnya untuk sintesis asam lemak dan steroid. 2.
Heksosa Monofosfat Shunt (Pentosa fosfat Shunt/HMP Shunt) Oksidasi Glukosa melalui pembentukan pentosa fosfat, yang reaksinya membutuhkan akseptor H yaitu NADP. Reaksi ini aktif dalam jaringan hati, mamma laktasi, adiposa eritrosit, testis, cortex adrenal. Enzim berada di ekstra mitokondria yang berguna untuk menghasilkan
29 sty 2019 · The HMP shunt plays a significant role in NADPH 2 formation and in pentose sugars that are biosynthetic precursors of nucleic acids and amino acids. Cells can be protected from highly reactive oxygen species by NADPH 2. Deficiency in the hexose monophosphate pathway is linked to numerous disorders.
Fungsi utama jalur ini adalah untuk menghasilkan NADPH, yaitu dengan mereduksi NADP +. NADPH diperlukan untuk proses anabolik di luar mitokhondria, seperti sintesis asam lemak dan steroid. Fungsi yang lain adalah menghasilkan ribosa-5-fosfat untuk sintesis nukleotida dan asam nukleat. Jalannya reaksi sebagai berikut ( gambar 18-19 ):
The HMP shunt is the primary source of erythrocyte NADPH, with 2 moles of NADPH produced for each mole of glucose metabolized. NADPH is required for the reduction of oxidized glutathione and some protein sulfhydryl groups. Mature erythrocytes synthesize large amounts of reduced glutathione (GSH).
