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make important recommendations that include the recognition of high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker, endorsement of 99th percentile upper reference limits to define myocardial injury, and the use of clinical decision
14 lip 2022 · This primer discusses the use of high-sensitivity cardiac troponin (hs-cTn) testing in context of the 2021 multisociety guidelines for the evaluation and diagnosis of acute chest pain, with a notable focus on analytical aspects of the hs-cTn assays and their implications.
22 lis 2011 · Based on the 99th percentile rule, troponin decision limits of several high-sensitivity cTn assays can be set as low as 0.01 ng/mL. 6 This makes it possible to identify patients with ACS earlier, enabling earlier coronary intervention (Figure 2).
1 lip 2022 · Analytical considerations in deriving 99 th percentile upper reference limits for high-sensitivity cardiac troponin assays: educational recommendations from the IFCC committee on clinical application of cardiac bio-markers [published online June 18, 2022].
28 mar 2022 · High-sensitivity troponin assays are used to detect troponins, but at a much lower concentration than classical assays. These assays offer several advantages, first of all being the fact that they are highly sensitive, thus providing faster recognition of AMI (rule-in/rule-out).
High-sensitivity cardiac troponin I (hs-cTnI) is a marker of subclinical cardiomyocyte damage associated with cardiovascular risk in middle-aged adults. We hypothesized hs-cTnI would be indicative of mortality and cardiovascular risk beyond traditional cardiovascular risk factors in older adults and may be more discriminatory compared to hs ...
The delta (or rate of rise) of repeat troponins over 1-3 hours is important in interpreting detectable troponins. Rapidly rising OR falling troponins outside of the Delta threshold are indicative of myocardial injury even if below the 99th percentile. Delta 0-15 ng/L (up OR down) – Approximately 20% of 99th%ile.
