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Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are members of the Herpesviridae family and are characterized by their ability to establish latency after primary infection and subsequently reactivate. HSV infections in the neonatal and pediatric populations range from uncomplicated mucocutaneous diseases to severe, life-threatening ...
15 lip 2024 · Recurrent infections — Oral HSV-1 recurrences occur when the virus reactivates from the trigeminal sensory ganglion, where it persists in a latent state. Symptomatic reactivation leads to oral herpes ("cold sores"), which occur along the vermillion border of the lips. Intraoral recurrences also can occur.
18 mar 2024 · Practice Essentials. Herpes simplex virus (HSV) infections are ubiquitous and have a wide range of clinical manifestations (see the images below). Beyond the neonatal period, most primary HSV-1...
Thereafter, HSV-1 occasionally reactivates in the ganglia, travels anterograde in the neurons, and causes recurrent clinical infection. Reactivations tend to occur more frequently in the months after the primary infection, but in some children, reactivations continue for years thereafter.
Although antiviral therapy was proven to decrease mortality from herpes simplex encephalitis with the institution of vidarabine therapy in the late 1970s, it was not until much later (1986) that acyclovir was proven to be beneficial in the treatment of biopsy-proven herpes simplex encephalitis 13.
23 maj 2023 · Christine Johnston & Lawrence R. Stanberry. 112 Accesses. 1 Citations. Abstract. Human herpes viruses 1 and 2 (HSV-1 and HSV-2) are closely related, double stranded DNA viruses of the alpha herpes virus family. Like the other six herpes viruses that infect humans, they cause incurable, chronic infections.
21 cze 2023 · Worldwide, an estimated 67 percent of the population has herpes simplex virus type 1 (HSV-1) infection. HSV-1 is typically transmitted from person to person via infected oral secretions during close contact. After initial infection, HSV-1 establishes chronic infection in sensory ganglia and reactivates on mucosa and skin.
