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  1. Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are members of the Herpesviridae family and are characterized by their ability to establish latency after primary infection and subsequently reactivate. HSV infections in the neonatal and pediatric populations range from uncomplicated mucocutaneous diseases to severe, life-threatening ...

  2. 15 lip 2024 · Recurrent infections — Oral HSV-1 recurrences occur when the virus reactivates from the trigeminal sensory ganglion, where it persists in a latent state. Symptomatic reactivation leads to oral herpes ("cold sores"), which occur along the vermillion border of the lips. Intraoral recurrences also can occur.

  3. 18 mar 2024 · Beyond the neonatal period, most childhood herpes simplex virus infections are caused by HSV-1. The seroprevalence of HSV-1 antibodies increases with age, and its rate is 20% by age 5 years.

  4. Keywords: Herpes simplex virus, antiviral compounds, Herpes encephalitis, CRISPR/Cas9, vaccine, HSV-1, HSV-2. Introduction. Herpes simplex virus (HSV) infections have been reported since ancient Greek times 1, 2. During the 20th century, the clinical manifestations of these infections were broadly reported in the medical literature.

  5. 28 sie 2023 · Objectives: Describe the pathophysiology of a herpes type 1 infection. Review the risk factors for herpes type 1 infection. Explain the presentation of a patient with herpes type 1 infection.

  6. It is transmitted through direct contact with a person during the primary infection, recurrence, or asymptomatic viral excretion. 1 The first contact with HSV‐1 occurs mainly during childhood, especially between 6 months and 3 years after the loss of maternal antibodies. 2 This infection is most often asymptomatic, or almost, with rough clinical...

  7. 13 wrz 2024 · Key facts. An estimated 3.8 billion people under age 50 (64.2%) globally have herpes simplex virus type 1 (HSV-1) infection, the main cause of oral herpes. An estimated 519.5 million people aged 15–49 (13.3%) worldwide have herpes simplex virus type 2 (HSV-2) infection, the main cause of genital herpes.

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