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19 kwi 2002 · We review our current understanding of the V (D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V (D)J recombination can lead to human disease.
1 sty 2024 · HTGTS-V(D)J-seq employs the target sequences of endogenous RAG-initiated breaks (e.g. an RSS or coding segment) as ‘bait’ to capture junctions of the RAG-generated break at the bait site and target DSBs during V(D)J recombination.
23 sty 2004 · V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports—the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.
V (D)J recombination assembles immunoglobulin and T cell receptor genes during lymphocyte development through a series of carefully orchestrated DNA breakage and rejoining events. DNA cleavage requires a series of protein-DNA complexes containing the RAG1 and RAG2 proteins and recombination signals that flank the recombining gene segments.
13 paź 2003 · The mechanism that generates variation in the antigen-binding pockets of these receptors involves mixing and matching variable (V), diversity (D), and joining (J) gene segments in a process called V(D)J recombination.
29 maj 2024 · To identify key mechanistic elements for diffusional V (D)J recombination in Igk versus Igh, we assayed Vκ-to-J H and D-to-Jκ rearrangements in hybrid Igh–Igk loci generated by targeted...
21 lis 2014 · V (D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation.
