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  1. 23 sie 2024 · Explore the effectiveness of grape seed extract and grapefruit seed extract in treating melasma. This comprehensive article delves into their understanding, mechanisms of action, clinical studies, safety, and real-world applications.

  2. Grape seed extract. Grape seed extract contains proanthocyanidin, which is a powerful antioxidant. Although, there are no studies on the topical use of grape seed extract, but oral intake for 6 months has been found beneficial in patients with melasma in a study conducted by Yamakoshi, et al.

  3. Vitamin E, niacinamide, polypodium leucotomos, pycnogenol, grape seed extract, amino fruit acids, phytic acid, zinc, silymarin, Korean red ginseng powder, plant extracts, and parsley all have well-demonstrated evidence of antioxidant properties, and these substances have been studied in the context of skin hyperpigmentation.

  4. Yamakoshi et al. demonstrated the skin-lightening property of proanthocyanidin-rich grape seed extract in the treatment of melasma on Japanese women. Thus, most of these agents are used as over-the-counter adjuncts without much credible scientific evidence.

  5. 26 lip 2024 · Explore the potential of grapefruit seed extract and grape seed extract in treating melasma. Learn how they work, scientific studies, benefits, drawbacks, and alternatives. Plus, precautions and recommendations for use.

  6. Hydroquinone monotherapy and triple combination cream are the most effective and well-studied treatments for melasma, whereas chemical peels and laser- and light-based therapies are equal or inferior to topicals, but offer a higher risk of adverse effects.

  7. 1 mar 2019 · Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study. Journals. Cosmetics. Volume 6. Issue 1. 10.3390/cosmetics6010015.