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Numerous studies have shown efficacy of various antioxidant therapies for treatment of hyperpigmentation, and in this review, we focus primarily on those with less widespread use.
Grape seed extract. Grape seed extract contains proanthocyanidin, which is a powerful antioxidant. Although, there are no studies on the topical use of grape seed extract, but oral intake for 6 months has been found beneficial in patients with melasma in a study conducted by Yamakoshi, et al.
Key Points. Melasma has a significant effect on quality of life due to its disfiguring appearance, chronic course, and recalcitrance to treatment. Topical hydroquinone alone or combined with a retinoid and a corticosteroid has the greatest evidence of efficacy in the treatment of melasma.
Chloasma (melasma), an acquired hypermelanosis, is often recalcitrant to various treatments and an amenable, as well as safe, pigment-reducing modality is needed. We investigated that the reducing effect of proanthocyanidin, a powerful antioxidant, on chloasma in a one-year open design study.
1 mar 2019 · The studied oral nutritional dietary supplement containing Pinus pinaster bark extract, Grape seed extract, vitamins and minerals is effective and well tolerated as a treatment option for mild to moderate facial melasma in combination with high SPF sunscreen.
21 maj 2019 · The grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications.
14 lis 2020 · This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity.
