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  1. The approval of once daily liraglutide, 3.0 mg, and once weekly semaglutide, 2.4 mg, for chronic weight management provides a novel effective strategy against obesity. The reliable models that might predict weight reducing potential at the individual level have not been identified yet.

  2. SMG is an analog of long-acting GLP-1, mainly used to control T2DM, and is also suitable for promoting weight loss in people with mild obesity (95, 96). The usage for treating obesity is subcutaneous injection once a week. For both diabetic and non-diabetic patients, the drug can reduce weight (97, 98).

  3. Current guidelines for the treatment of obesity in adults suggest escalation of therapeutic measures according to BMI and the presence of comorbidities.

  4. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were initially approved for improvement of metabolic control in patients living with diabetes. 1 However, recent randomised controlled trials (RCTs) have demonstrated the efficacy of some GLP-1 RAs for weight reduction in adults even without diabetes, leading to semaglutide and liraglutide ...

  5. GLP-1RAs for the treatment of obesity in women after menopause. Maturitas. 2022 Feb:156:65-66. doi: 10.1016/j.maturitas.2021.12.003. Epub 2021 Dec 11. Authors. Stavroula A Paschou 1 , Kalliopi Kotsa 2 , Melpomeni Peppa 3 , Erifili Hatziagelaki 3 , Theodora Psaltopoulou 4. Affiliations.

  6. 24 kwi 2022 · Dane oparte na dowodach jednoznacznie potwierdziły zasadność stosowania analogów peptydu glukagonopodobnego 1 (GLP-1) w leczeniu pacjentek z nadwagą/otyłością i PCOS. Efektem terapii GLP-1 jest nie tylko redukcja masy ciała, ale także poprawa wskaźników insulinooporności oraz zmniejszenie hiperandrogenemii.

  7. 1 paź 2022 · Objective. To determine effects of glucagon-like peptide-1 (GLP-1) receptor agonists on ≥5% or ≥10% weight loss in overweight or obese patients with or without type 2 diabetes mellitus (T2DM). Methods. A systematic review and meta-analysis of placebo-controlled, randomized clinical trials (RCTs) ≥12 weeks’ duration.

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