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Explore the diverse roles of globoside in cellular processes, disease pathogenesis, and therapeutic strategies. Learn about its structural composition, functional implications, and analytical techniques.
Globosides are a class of glycosphingolipids that play crucial roles in various biological processes. Analyzing these complex molecules is essential to understand their structural diversity and functions in health and disease. We offer various effective methods for Globoside analysis. High-Performance Liquid Chromatography (HPLC).
15 mar 2017 · Gangliosides are synthesized by stepwise addition of monosaccharides to ceramide (Cer). Ceramide is the acceptor for UDP-Glc p (ceramide β- d -glucosyltransferase). Extension of GlcCer occurs through the action of UDP-Gal p (GlcCer β1,4-galactosyltransferase) to make lactosylceramide (LacCer).
4 lip 2017 · Gangliosides are acidic glycosphingolipids containing one or more sialic acid residues. They are essential compounds at the outer leaflet of the plasma membrane, where they interact with phospholipids, cholesterol, and transmembrane proteins, forming lipid rafts.
Based on development of various methodologies for isolation and characterization of glycosphingolipids (GSLs), we have identified a number of GSLs with globo-series or lacto-series structure. Many of them are tumor-associated or developmentally-regulated antigens. The major question arose, what are their functions in cells and tissues?
Most common examples are galactosylceramide (galactocerebroside) and glucosylceramide (glucocerebroside) with β- d -galactose and β- d -glucose as the monosaccharide unit, respectively. Prior to the biosynthesis, the sugar is activated through condensation with uridine diphosphate (UDP).
Globoside is an intermediate in the synthesis of more complex structures of the globo series of glycosphingolipids such as the Forsmann antigen, the stage-specific embryonic antigen 4 and globo-H.
