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23 cze 2021 · Here, we review statistical patterns in de novo germline mutations from parent–offspring trio sequencing and in human genetic variation data from large-scale genome sequencing projects.
6 wrz 2019 · In humans, most germline mutations are paternal in origin and numbers of mutations per offspring increase with paternal and maternal age. Here we estimate germline mutation rates and...
24 maj 2022 · Germline mutations are changes to your DNA that you inherit from the egg and sperm cells during conception. Somatic mutations are changes to your DNA that happen after conception to cells other than the egg and sperm.
25 wrz 2015 · Germline mutations are the principal cause of heritable disease and the ultimate source of evolutionary change. Similarly, somatic mutations are the primary cause of cancer and may contribute to the burden of human disease more broadly than previously appreciated.
3 cze 2019 · Germline mutations are inherited through one of five main patterns: autosomal recessive, autosomal dominant, X-linked dominant, X-linked recessive or mitochondrial maternal.
In plants, somatic cells become germline cells; so somatic mutations can become germline mutations. Take a look at the video below, 2H – Somatic & germline mutations, presented by Professor Redfield of UBC (Useful Genetics, 2015) on YouTube, which explains Somatic and Germline mutations.
In contrast to somatic mutations, we found remarkable consistency of germline mutation spectra between the sexes and at different paternal ages. 3.8% of mutations were mosaic in the parental germline, resulting in 1.3% of mutations being shared between siblings.
