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16 sty 2015 · In this study, we found that all six members of the GATA transcription factor family could substitute for Oct4 and reprogram mouse somatic cells to pluripotency. Additionally, all six members...
22 paź 2018 · (A) The six murine members of the GATA family of transcription factors are grouped as GATA1/2/3 and GATA4/5/6 based on expression and similarity. They contain two highly conserved zinc-finger domains (Zn), a nuclear localization signal (NLS) and the less conserved C-terminal and N-terminal regions, the latter of which contains transcriptional ...
24 wrz 2014 · We find that GATA4 binds and participates in establishing active chromatin regions by stimulating H3K27ac deposition, which facilitates GATA4-driven gene expression. GATA4 chromatin occupancy...
2 paź 2024 · GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2. Among its related pathways are Gene expression (Transcription) and Cardiac conduction.
26 maj 2022 · GATA1/2/3 are hallmarks of hematopoietic cell lineages, and consequently are essential for the differentiation of multiple blood cell types (erythrocytes, leukocytes, megakaryocytes) [reviewed in (1, 2)]. By contrast, the GATA4/5/6 proteins (known as the cardiac family of GATA factors) populate tissues of mesodermal and endodermal origin such ...
1 sty 2010 · In conclusion, GATA4 and 6 are essential for embryonic heart formation, and play critical roles in postnatal heart development and maintenance of cardiovascular function. Thus, GATA4 and 6 are part of the regulatory pathways that are shared between the embryonic and the adult heart. VI. Role of GATA4 in Cardiomyocyte Survival
17 kwi 2021 · In this study, we aimed to investigate whether regulatory variants in GATA4 gene may change GATA4 levels, conferring susceptibility to T2D development. The promoter region of GATA4 gene was analyzed by targeted sequencing in T2D patients (n = 255) and ethnic-matched controls (n = 371).
