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Our data suggest that GATA-4 could be a novel potential therapeutic target, and miR-497 could serve as a potential non-invasive biomarker for high-grade meningioma. Meningioma is the most frequent primary intracranial tumour.
In humans and animal models, GATA4 has been demonstrated to be essential for normal cardiogenesis because it is highly expressed in cardiomyocytes at different developmental stages and continues expression in the adult cardiac myocytes, where it regulates the transcription of several key structural and regulatory genes including atrial ...
22 paź 2018 · The conditional deletion of Gata4 (using Wt1 Cre) in the coelomic epithelium results in a complete absence of genital ridge formation and a failure to initiate testis and ovary development (Hu et al., 2013). Hence, GATA4 is an early and essential driver of gonad formation in both male and female embryos.
GATA binding protein 4, a transcription factor upregulated in malignant meningioma, caused increased cell viability by controlling the expression of the miR-497~195 cluster, resulting in increased Cyclin D1 expression.
GATA4 is a prognostic marker in Ovary serous cystadenocarcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.
11 mar 2022 · We show that GATA4/5/6 family members play key, conserved, and early roles in cardiac versus pharyngeal fate separation. This implies that precisely controlled GATA4/5/6 expression
Interpretation: Our data suggest that GATA-4 could be a novel potential therapeutic target, and miR-497 could serve as a potential non-invasive biomarker for high-grade meningioma.
