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22 paź 2018 · Here, we briefly discuss the molecular hallmarks and mode of action of GATA proteins, review the different developmental systems in which GATA members have been implicated and link these findings to human disease. Fig. 1. The GATA family of proteins.
30 mar 2023 · Individuals who become symptomatic with GATA2 deficiency, typically present in their late teens or early twenties, and ultimately succumb to either disseminated infections, MDS, or AML within 2 to 20 years.
13 kwi 2017 · In this review, we focus on the hematopoietic factors GATA1 and GATA2 and the contributions of their alterations in benign and malignant blood diseases. GATA1 is an X-linked gene that encodes a DNA binding protein with two zinc fingers and a transactivation domain.
Specific antibody deficiency is a primary antibody deficiency characterized by normal levels of immunoglobulins and subclasses, recurrent sinopulmonary infections, and poor response to polysaccharide antigens after vaccination.
30 cze 2021 · GATA4 gene regulatory region was investigated in the patients with atrial septal defects (ASD) (n = 332) and ethnic-matched controls (n = 336).
17 kwi 2021 · In this study, we aimed to investigate whether regulatory variants in GATA4 gene may change GATA4 levels, conferring susceptibility to T2D development. The promoter region of GATA4 gene was analyzed by targeted sequencing in T2D patients (n = 255) and ethnic-matched controls (n = 371).
18 wrz 2024 · Title: Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease.
