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14 paź 2016 · Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology.
13 cze 2019 · The 3D organization of chromatin modulates biological processes such as transcription, DNA replication, cell division and meiosis, which are crucial for cell differentiation and animal...
8 cze 2020 · When modeling the three-dimensional (3D) structure of chromosomes, there are two commonly used approaches: inverse (or fitting-based) models and forward (or mechanistic) models.
21 gru 2022 · 3D chromatin organization (shown by Hi-C contact map) and phase separation are highly dynamic and play functional roles during early embryonic development, cell differentiation, somatic reprogramming, cell transdifferentiation and pathogenetic process.
The 3D organization of chromatin modulates biological processes such as transcription, DNA replication, cell division and meiosis, which are crucial for cell differentiation and animal development. In this Review, we discuss recent progress in our understanding of the general principles of chromatin folding, its regulation and its functions in ...
13 lis 2020 · Recent advances in image-based 3D genomics techniques have enabled direct tracing of chromatin folding and multiplexed imaging of nucleome architectures in single cells of several important biological systems.
1 lip 2020 · RESULTS. Deep-PALM reveals dynamic chromatin remodeling in living cells. Super-resolution imaging of complex and compact macromolecules such as chromatin requires dense labeling of the chromatin fiber to resolve fine features.
