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2 lut 2021 · In infarcted adult mouse heart, a single administration of agrin promotes cardiac function recovery (Bassat et al., 2017). Furthermore, decreasing ECM stiffness is able to prolong the time window of regenerative capacity in neonatal mouse heart (Notari et al., 2018 ).
3 lis 2020 · While focusing on restoring heart muscle and replenishing lost coronary vessels is clearly important, mounting evidence suggests that achieving full regeneration will require fibroblast, immune, conductive, and nervous cell contributions to the regenerative process.
21 wrz 2017 · Key Points. Reverse remodelling is the process by which failing myocardium demonstrates normative changes in chamber geometry and function, and might also include correction of molecular and...
3 gru 2021 · Various approaches have been tested to repair cardiac damage and restore heart function in the past few decades. These strategies include cell-based, non-cellular, induced adult cardiomyocyte proliferation and manipulation of cardiac remodeling.
25 cze 2020 · Indeed, specific deletion of Fgfr1 and Fgfr2 in CECs in mice impaired cardiac functional recovery and diminished vascular remodelling after MI, implicating a beneficial role for this pathway...
7 sty 2021 · While ex vivo methods can introduce artificial scenarios, each can provide valuable insights into functional capabilities. In this review we will consider the methodology for several commonly used ex vivo methods of assess cardiac function as well as the strengths and limitations of each.
Current knowledge on the extent of cardiac (reverse) remodelling primarily relies on imaging techniques, notably echocardiography and cardiac magnetic resonance (CMR). These methods gauge cardiac chamber dimensions, LV mass (LVM), and functional parameters such as LVEF and myocardial strain.
