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25 paź 2021 · We created a simplified 2D approach that isolates biomechanical inputs on cardiac muscle development and demonstrated that the biomechanical environment is independently a critical...
25 cze 2020 · Coronary vessels require perivascular support, with arteries surrounded by multiple layers of smooth muscle, whereas capillaries are in direct contact with individual pericytes.
19 kwi 2022 · A modified, dense and crosslinked microtubule network increases the viscoelastic resistance to cardiomyocyte motion in heart failure, which can contribute to elevated myocardial stiffness.
Calcium transients, required to trigger contraction, can be detected even earlier, prior to contraction. In this review, we outline what is currently known about how this early contractile function is initiated and the impact early contractile function has on cardiac development.
25 maj 2020 · In the healthy heart, cardiomyocytes (CMs) are exposed to the passive stiffness of the cardiac muscle (independent of the muscle activity) and to the active force of the heart contractile apparatus.
1 cze 2022 · Here, we highlight recent research advancements on cellular sources and molecular mechanisms of coronary vessel formation during heart development and regeneration, and also elaborate on how these mechanisms can be reactivated or recapitulated to facilitate therapeutic revascularization in ischemic heart disease.
9 gru 2008 · This report (1) details observed patterns of cardiac dynamic directional and twisting motions via multiple imaging sources; (2) summarizes the deficiencies of correlations between ventricular function and known ventricular muscle architecture; (3) correlates known cardiac motions with the functional anatomy within the helical ventricular ...