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25 cze 2020 · Coronary vessels require perivascular support, with arteries surrounded by multiple layers of smooth muscle, whereas capillaries are in direct contact with individual pericytes.
4 dni temu · We propose that Lmpt may participate in cardiac development through the dmef2-Lmpt/Mlp84B molecular pathway and could function as a coactivator of Mlp84B biological activity in the developing heart (Fig. 1B) . However, the downstream target genes of Lmpt in regulating cardiac development remain unclear.
13 mar 2024 · To understand how the human ventricle forms and organizes the myocardial layers pivotal for its development and function, we focused on investigating how distinct cardiac cells coordinate to...
25 maj 2020 · In the healthy heart, cardiomyocytes (CMs) are exposed to the passive stiffness of the cardiac muscle (independent of the muscle activity) and to the active force of the heart contractile apparatus.
1 cze 2022 · Unraveling cellular sources and molecular mechanisms of coronary vessel formation during heart development and regeneration provides important insights into developing effective strategies for heart revascularization.
17 gru 2018 · Heart regeneration can recapitulate the processes that occur during heart development. In this review, we will summarize the cell types and signaling pathways involved in coronary vessel development with a focus on non-mammalian models.
3 lis 2020 · A pro-regenerative chemical and mechanical microenvironment, mediated principally by fibroblast, macrophage and nervous system signalling, result in removal of scar tissue, cardiomyocyte division to replace lost muscle tissue, and generation of new vasculature.
