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13 mar 2024 · Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of...
24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease. Cardiovascular...
24 sty 2022 · Of note, we identified a set of cozonated genes shared by endothelial cells and pericytes, confirming their synergistic functions in maintaining vascular function (Figure [M and N]). We built an interactive database ( http://xglab.tech/hahca ) to visualize cellular gene expression and zonation.
28 lut 2022 · In this review, we described a variety of emerging approaches that have been developed to evaluate the contractile functions of in vitro cardiac models at the cellular and tissue levels.
25 cze 2019 · Instead 3D culture mimics features of larger tissues or entire organs and is the method of choice for co-culture models. 3D cardiac cell culture technologies hold great potential for applications in tissue engineering, drug development, cardio-toxicology and disease modeling.
14 wrz 2021 · Human heart (patho)physiology is now widely studied using human pluripotent stem cells, but the immaturity of derivative cardiomyocytes has largely limited disease modeling to conditions associated with mutations in cardiac ion channel genes.
Highlights. •. scRNA-seq analysis revealed diverse cell lineages of the developing zebrafish heart. •. Molecular diversity of myocardial subpopulations suggests functional specializations. •. Novel role of pacemaker-enriched atp1b3b and colec10 in heart rate and morphogenesis. •.
