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1 kwi 2009 · Many ion channels function as part of macromolecular complexes in which many components are assembled at specific sites within the membrane. This review describes the generation of the normal cardiac action potential. The properties of the major ionic currents are the examined in detail.
24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease. Cardiovascular...
5 mar 2021 · In this Review, we discuss the diverse roles the ECM plays during cardiac development, from the formation of the linear heart tube through to heart maturation, focussing on how ECM modification and turnover are emerging as central themes in regulating distinct aspects of morphogenesis.
Cardiac cells communicate via cell-cell contacts (e.g., adhesion molecules, gap junctions), paracrine/autocrine signaling (e.g., cytokines, growth factors), and metabolites (e.g., ROS,...
30 paź 2023 · They extend across the membranes of juxtaposed cells, creating direct pathways for ions to flow. This allows all the cells of the heart to contract in synchrony. The desmosomes and fascia adherens are anchoring proteins that hold the myofibrils and the cardiomyocyte’s cytoskeleton in place.
23 maj 2000 · In this study, we showed that EFS create secondary and tertiary membrane potential sources at nonlinear tissue structures (bifurcating cell strands, abrupt expansions, and bending strands).
8 sie 2010 · These include paracrine/autocrine and endocrine signals, direct cell-cell contacts via gap junction, and cell- matrix interactions between cells of the coronary vasculature, cardiomyocytes, fibroblasts and probably other cell types, including tissue-resident stem cells.
