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17 sie 2023 · The cardiac conduction system is a network of specialized cardiac muscle cells that initiate and transmit the electrical impulses responsible for the coordinated contractions of each cardiac cycle.
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A comprehensive analysis of cell generation and turnover in the human heart demonstrates that cardiomyocyte numbers are constant throughout the human lifespan, with a low turnover rate. Endothelial and mesenchymal cells are exchanged at a high rate, and their numbers increase into adulthood.
1 paź 2021 · Myocardial infarction and cardiac pressure overload induce regional patterns of cycling cardiomyocytes. Mechanistically, cardiomyocyte cell cycle activity requires the Hippo pathway effector YAP.
28 wrz 2018 · Key points. Clonal analysis shows that two myocardial cell lineages, which segregate early at gastrulation, form the heart, with cell sublineages contributing to the arterial and venous poles,...
24 wrz 2020 · Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease.
28 sie 2017 · This review focuses on the cardiac cell cycle and its variants during postnatal growth, the different regenerative responses of the heart in dependance of the developmental stage and on manipulations of the cell cycle.
29 kwi 2024 · The FUCCI system allows the assessment of cycling and non-cycling cells, but the approach is limited by the rare activation of cycling cardiomyocytes in adult hearts after cardiac injury and the inability to label daughter cells to identify endoreplicative and authentic cell division in vivo.
