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Use of Antibiotics for Treating UTIs in Dogs and Cats. Complicated, relapsing, recurrent, and refractory UTI may be challenging to cure. Understanding drug PK/PD and potential alterations in the animal’s metabolism/excretion of the drug can help increase the likelihood of successful treatment. February 10, 2017 |.
- JD Foster
Urinary Tract Infections in Dogs. Most UTIs are successfully...
- JD Foster
Selected antimicrobials: amoxicillin, amoxicillin clavulanate, cephalosporins, trimethoprim-sulfadiazine and enrofloxacin. Drugs should be given in 2 to 3 equal subdoses per day, and one of the dose administered prior to a period of confinement.
Fosfomycin, a phosphonic acid which contains a carbon-phosphorus bond, is a natural antibiotic produced by Streptomyces fradiae. Its in vitro spectrum is broad, with potential efficacy toward isolates expressing MDR, including E. coli and gram-positive isolates.
2.1.2. Treatment of Uncomplicated UTIs. Antimicrobial ther-apy is indicated in most cases while awaiting culture and susceptibility results to relieve patient discomfort. In most situations, initial therapy should consist of amoxicillin (11– 15mg/kg PO q8h) or trimethoprim-sulfonamide (15mg/kg PO q12h) (Tables 1 and 2). Amoxicillin/clavulanic ...
Vancomycin, imipenem-cilastatin, meropenem, fosfomycin, quinupristin-dalfopristin, and tigecycline should not be used routinely in the treatment of UTIs in animals. Nonantimicrobial control of infection should be considered whenever feasible.
Discussion. UTI is an exceedingly common type of bacterial infection that affects healthy individual as well as those with comorbidity. Most UTIs are caused by E. coli. 1 3 4 In the present study, E. coli was isolated in 82% of cases, which also reflected the etiology of UTI in the general adult population. 1 3 4 8. There is an increase in literature on the use of fosfomycin in UTIs from the ...
5 maj 2020 · This study investigated the urinary pharmacokinetic/pharmacodynamic (PK/PD) profile of fosfomycin orally administered at 80 mg/kg to six healthy dogs to assess its efficacy for canine urinary tract infections (UTIs) caused by ESBL-producing bacteria.
