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The present work provides an improved synthesis process of FCM as an intravenous iron, active pharmaceutical ingredient. Methods: Water-soluble FCM complex was prepared from the reaction of ferric hydroxide precipitation with an aqueous solution of oxidized maltodextrin (MD) at optimum temperature and pH conditions.
IN3463/MUM/2011 discloses a process for the preparation of ferric carboxymaltose comprising oxidation of maltodextrin with sodium hypochlorite to provide oxidized maltodextrin followed by...
14 sty 2021 · Background Ferric carboxymaltose (FCM) formulation consists of iron–carbohydrate nanoparticles that iron– oxyhydroxide as a core is covered by carbohydrate shell. The present work provides an...
Background: Ferric carboxymaltose (FCM) formulation consists of iron-carbohydrate nanoparticles where iron-oxyhydroxide as a core is covered by a carbohydrate shell. The present work provides an improved synthesis process of FCM as an intravenous iron, active pharmaceutical ingredient.
1 lut 2020 · FCM is a polynuclear iron (III)-hydroxide carboxymaltose complex with a molecular weight of ~150,000 Da. It is formulated as a colloidal solution with a near-neutral pH (5.0–7.0) and a physiological osmolarity permitting administration of higher single doses in short time periods.
1 sty 2009 · Ferric carboxymaltose (FCM) is an intravenous iron agent incorporating a complex of ferric hydroxide and attached carbohydrate, offering sustained iron delivery to reticuloendothelial cells...
Ferric carboxymaltose (FCM, marketed as Ferin-ject®) is a new intravenous iron preparation. It combines the positive characteristics of iron dextran and iron sucrose but is not...
