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1 kwi 2020 · Fentanyl and methadone are considered safe in renal failure. 19 Similarly, prescribing opioids in the setting of liver failure is also complex. Because most opioids are metabolized in the liver, the risk of adverse effects is much higher.
The side effect profile of opiates is similar for all age groups; however the elderly population is at a greater risk for these side effects given their comorbidities and high incidence of polypharmacy.
Another side effect of high-dose opioids is respiratory depression, which is more common in elderly people. This effect is mediated by the μ-opioid receptor, to which agonists such as morphine and fentanyl have a distinct dose-dependent effect [ 14 ].
Conclusions: Overall, central nervous system adverse effects were most commonly seen in the elderly. However, higher quality evidence is required to further appreciate the dose-related effects on efficacy and safety of opioids in the elderly. Keywords: opioid, elderly, older adult, persistent pain. Introduction.
16 cze 2016 · The use of opioid analgesics in the treatment of moderate to severe pain in people of advanced age is additionally complicated by the presence of other diseases (comorbidities) and the use of other medications which increases the risk of possible interactions.
12 sie 2019 · Relevance to Patient Care and Clinical Practice: As there is a lack of strong evidence-based recommendations for opioid use in the elderly, this review aims to evaluate opioid use in the elderly and compare their efficacy and safety among this population.
Opioids are commonly employed to treat pain but must be approached with caution due to potentially dangerous adverse reactions. This article provides strategies for safely prescribing opioids for pain in older adults. NPs are seeing increasing numbers of older adults in most clinical settings.
