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21 lut 2017 · This document provides an overview of local anaesthesia including: - A definition and historical background of local anaesthetics such as cocaine and procaine. - Desirable properties and classifications of local anaesthetics.
- Local anesthetic agents
It discusses pharmacokinetics including uptake,...
- local anaesthesia drugs
local anaesthesia drugs. Local anesthetics work by blocking...
- Local anesthetic agents
3 sie 2019 · It discusses pharmacokinetics including uptake, distribution, metabolism and excretion. It also covers factors affecting drug action and applications of local anesthetics in different surgical procedures. Read less
16 mar 2023 · local anaesthesia drugs. Local anesthetics work by blocking sodium channels and include both ester and amide chemical structures. Ester local anesthetics like procaine are metabolized rapidly via plasma esterases while amides like lidocaine undergo hepatic metabolism.
7 sie 2014 · Presentation Transcript. Pharmacology of Local Anesthetics Outline • History • Chemistry and Structure-Activity Relationships • Mechanism of Action • Pharmacological effects and toxicities • Clinical aspects.
There are 2 classes of local anaesthetic drugs defined by the nature of the intermediate chain. All LA cross BBB and placenta Amides • Bupivacaine • Lidocaine • Mepivacaine • Prilocaine • Ropivacaine Ester • Cocaine • Procaine • Chlorprocaine • Tetracaine. 7 Common Uses Of Local Anaesthetics: Dentistry Dermatology Excision Spinal Anaesthesia.
Local anesthetics work by reversibly blocking sodium channels and preventing the propagation of action potentials. This produces a loss of sensation in the applied area without loss of consciousness. There are two main classes - esters and amides - which differ in how they are metabolized.
Download ppt "Pharmacology of local anesthetics". History Local anesthesia was accomplished by having the operator chew coca leaves and apply the mascerated pulp to the skin and wound edges while using a tumi knife to bore through the bone.
