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16 mar 2023 · local anaesthesia drugs. Local anesthetics work by blocking sodium channels and include both ester and amide chemical structures. Ester local anesthetics like procaine are metabolized rapidly via plasma esterases while amides like lidocaine undergo hepatic metabolism.
- Local anesthetic agents
The document outlines the anatomy and physiology of neurons...
- "LOCAL-ANAESTHESIA"
This document provides an overview of local anaesthesia...
- Local anesthetic agents
3 sie 2019 · The document outlines the anatomy and physiology of neurons involved in nerve conduction and the mechanism of action of local anesthetics in blocking nerve conduction. It discusses pharmacokinetics including uptake, distribution, metabolism and excretion.
21 lut 2017 · This document provides an overview of local anaesthesia including: - A definition and historical background of local anaesthetics such as cocaine and procaine. - Desirable properties and classifications of local anaesthetics. - Details on common local anaesthetics like lidocaine including mechanism of action, dosage, and comparisons to other ...
Local anaesthetics (LAs) are applied to block nociception (pain perception) that is transmitted peripheral Aδ and C nerve fibres to the brain. Chemically, LAs are amphiphilic molecules with a hydrophobic aromatic group and a basic amine group.
There are 2 classes of local anaesthetic drugs defined by the nature of the intermediate chain. All LA cross BBB and placenta Amides • Bupivacaine • Lidocaine • Mepivacaine • Prilocaine • Ropivacaine Ester • Cocaine • Procaine • Chlorprocaine • Tetracaine. 7 Common Uses Of Local Anaesthetics: Dentistry Dermatology Excision Spinal Anaesthesia.
Local anesthetics Drug produce reversible conduction block of neural impulses transmission of autonomic, sensory and motor neural impulses.
Download ppt "Pharmacology of local anesthetics". History Local anesthesia was accomplished by having the operator chew coca leaves and apply the mascerated pulp to the skin and wound edges while using a tumi knife to bore through the bone.
