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1 maj 2019 · A deletion mutation is a mistake in the DNA replication process which removes nucleotides from the genome. A deletion mutation can remove a single nucleotide, or entire sequences of nucleotides. Deletions are thought to occur when the enzyme that synthesizes new DNA slips on the template DNA strand, effectively missing a nucleotide.
1 cze 2024 · In the realm of genetics, a deletion mutation, often denoted by the symbol Δ, refers to a specific type of genetic aberration where a segment of a chromosome or a DNA sequence is omitted during the DNA replication process.
By definition, a mutation is a heritable change in DNA sequence. This can happen in several ways: substitution of a DNA base, insertion or deletion of one or more DNA bases, or by large-scale chromosomal rearrangements, the latter of which will not be considered here.
For example, single-stranded DNA breaks are repaired primarily by Base Excision Repair, bulky DNA adducts, and crosslinks are repaired by Nucleotide Excision Repair, and smaller nucleotide mutations, such as alkylation are repaired by Mismatch Repair.
Deletion is a genetic mutation that can result in some seriously bad effects. During DNA replication, deletion is when a section of the DNA sequence is lost. Deletions can range from a single nucleotide to an entire section of a chromosome.
Deletion mutations. In the top sequence three nucleotides comprising a single codon are deleted. This shortens the resulting protein product by one amino acid but does not affect the rest of its sequence. In the lower section, a single nucleotide is deleted.
A deletion mutation occurs when a wrinkle forms on the DNA template strand and subsequently causes a nucleotide to be omitted from the replicated strand (Figure 3).
