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Promote adequate growth and development. Provide nutrients for proper healing of skin lesions. Strengthen the immune system to fight infection. Provide energy. Aid with certain side effects of EB such as constipation. Improve overall quality of life.
23 kwi 2020 · Epidermolysis bullosa (EB) comprises a group of genetic disorders characterized by fragility of the skin and mucosal membranes. The molecular basis involves pathogenic variants in genes encoding structural proteins of the dermal–epidermal junction zone (DEJZ) [1].
2 sie 2024 · Epidermolysis bullosa (EB) comprises rare genetic disorders characterized by skin and mucosal membrane blistering induced by mechanical trauma. Molecularly, pathogenic variants affect genes encoding proteins crucial for epidermal–dermal adhesion and stability.
11 sty 2024 · Epidermolysis bullosa (EB) defines a prototypic group of rare, inherited dermatoses, characteristically featuring skin fragility secondary to structural defects in the dermo-epidermal junction. This skin fragility creates an impaired tolerance to mechanical stress.
The causative gene mutations of most EB types are known. The current international consensus classification contains four main types: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB), and Kindler syndrome (KS). The classification is based on the morphological level of blister formation.
5 lip 2023 · Recent breakthroughs in gene therapy continue to transform the landscape of therapies for epidermolysis bullosa (EB), offering encouraging outcomes for patients suffering from this severe blistering skin disease.
Epidermolysis bullosa research has advanced considerably in the past decade (Table 3), and wound and pain management has improved. Inclusion of several clinical disciplines in addition to dermatology has proven essential in order to provide comprehensive care for EB patients.
