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27 cze 2017 · Accumulating evidence from preclinical studies demonstrates that the endocannabinoid signaling system is involved in all of these diseases and disorders; hyperactivity of endocannabinoid...
Expression of cannabinoid type 1 and type 2 (CB 1 and CB 2) receptors in neural tissue. The endocannabinoid system is present in neurons, astrocytes, oligodendrocytes, oligodendrocyte precursor cells (OPCs), and microglia.
6 gru 2016 · The endocannabinoids bind to CB1 receptors in various brain regions to modulate behavioral functions in relation to cognition, emotionality, and stress [12, 103]. These results delineate the effects of CB1 receptor inactivation by utilizing convergent genetic and pharmacological approaches.
The endocannabinoid system (ECS) in the brain primarily influences neuronal synaptic communication, and affects biological functions—including eating, anxiety, learning and memory, reproduction, metabolism, growth and development—via an array of actions throughout the nervous system. In spite of recent scientific findings, there is much ...
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in the developing central nervous system as well as playing a major role in tuning many cognitive and physiological processes.
2 paź 2020 · This study aimed to investigate associations between basal serum concentrations of the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol (2-AG) with brain functional reward processing.
1 sty 2022 · These results, confirming preclinical data showing that AEF0117 does not produce any of the adverse effects associated with rimonabant, support an upcoming multisite randomized clinical trial to test AEF0117 in patients seeking treatment for cannabis use disorder.
