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We evaluated EGFR expression at protein and mRNA levels in canine intestinal adenocarcinomas using immunohistochemistry (IHC) and RNA in situ hybridization (RNA-ISH). We also investigated the mutation status of EGFR, KRAS, and BRAF to aid the development of anti-EGFR agents for canine intestinal adenocarcinoma.
Evidence of decreased GFR occurred commonly in older dogs of most breeds, especially geriatric dogs greater than 10 years of age, but there were some exceptions, with more significant changes affecting younger animals of several breeds. The combination of SDMA and Cr identified more cases of decreased GFR than either SDMA or Cr alone.
30 kwi 2021 · The EGFR, KRAS, and BRAF genes showed wild-type sequences at the mutation hot spots in all 13 specimens. Thus, EGFR might serve as a promising diagnostic marker in canine intestinal adenocarcinoma, and further studies would be needed to develop EGFR-targeted anticancer therapies.
15 sty 2014 · KRAS mutations activate RAS proteins that continuously stimulate the signalling pathways in the absence of upstream stimulation of EGFR (constitutive activation). Consequently, tumours bearing a KRAS mutation are less likely to respond to anti-EGFR drugs .
19 kwi 2024 · Common symptoms of kidney failure in dogs include increased thirst, lethargy, diarrhea, excessive urination, and dehydration. Kidney failure, or chronic kidney disease (CKD), is a progressive disease, meaning a dog’s kidney function gets worse over time.
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15 sty 2014 · A total of 19 canine gastric epithelial neoplasms (5 adenomas and 14 carcinomas) were retrospectively evaluated for EGFR/HER-2 immunohistochemical expression and KRAS mutational status. Five (35.7%) carcinomas were classified as intestinal-type and 9 (64.3%) as diffuse-type.
