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Eligible treatments included ALRV5XR, Dutasteride 0.5 mg/day, Finasteride 1 mg/day, low-level laser comb treatment (LLLT), Minoxidil 2% and 5%, Nutrafol, and Viviscal.
We performed this meta-analysis to evaluate the safety and efficacy of dutasteride and finasteride in treating AGA during a 24-week treatment cycle, and found significant differences between the two drugs for the mean change in total hair count, investigator’s assessment of global photographs for the vertex and frontal views, panel global ...
Minoxidil elicits its greatest effect at the vertex and frontal regions of the scalp where it is known to slow the rate of hair loss by prolonging the anagen phase and promote hair regrowth by increasing both hair diameter and density.
Dutasteride inhibits both type I and type II 5-alpha-reductase while finasteride inhibits only the type II enzyme. As both isoenzymes are present in hair follicles, it is likely that dutasteride is more effective than finasteride.
Oral dutasteride has a proven track record of success when it comes to improving hair growth, hair density, and scalp coverage in AGA. In clinical trials, dutasteride performed better than finasteride in hair regrowth and lowering DHT. In addition, significant type 1 5AR activity has been identified in the scalp.
Improvement in hair density (even without coexistence with androgenetic alopecia) and eyebrows has been documented. 2 It is possible that patients who experienced hair regrowth received treatment with dutasteride before establishing a cicatricial alopecia.
1 mar 2021 · Dutasteride. Dutasteride, a potent type I and type II 5-alpha reductase inhibitor, is used to treat benign prostatic hyperplasia, but is also prescribed as an off-label treatment for pattern hair loss.
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