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Skin tests are useful for platinum salt-related immediate hypersensitivity reactions (moderate/strong) 50, while for other chemotherapeutic drugs, experience is limited and test results often negative (low/weak).
When the history suggests a potential IgE-mediated mechanism, skin testing (skin prick and intradermal testing read at 15 to 20 minutes) to the drug(s) should be considered. Histamine should be used as positive control and saline as negative control.
1 sty 2024 · Skin tests are the most readily available tools for the evaluation of drug hypersensitivity reactions. A skin test reaction to a drug tested in a non-irritative concentration is indicative of a drug allergy and a potentially harmful drug provocation test can be avoided.
5 lut 2022 · Skin tests, including patch tests (PTs), prick tests, and intradermal tests (IDTs), are useful in identifying the culprits of cutaneous adverse drug reactions (CADRs), and determining safer, alternative drugs.
31 mar 2022 · A negative drug skin test does not exclude the responsibility of a drug in the occurrence of an adverse drug reaction. Patch tests (PTs) and skin tests (STs), namely skin prick tests (SPTs) and intradermal tests (IDTs), are useful tools for diagnosing drug hypersensitivity.
10 lis 2023 · If skin test results are negative, proceed to DC, with flexible protocols depending on presentation and risk (ie, full vs subtherapeutic dose, and multiple-day courses if necessary). Cross-reactivity assessments are also considered here, if deemed necessary.
In immediate drug reactions, an IgE-mediated mechanism can be demonstrated by a positive skin prick and/or intradermal test after 20 minutes, whereas in non-immediate reactions, a T-cell involvement can be found by a positive patch test and/or a late-reading intradermal test.
