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16 lip 2021 · Kidney replacement therapy (KRT) adds a layer of complexity to drug dosing because the clearance of dialyzable medications differs significantly during the time on dialysis compared with when the patient is not undergoing dialysis, and drug clearance depends on any residual kidney function.
27 lip 2024 · Renal disease primarily affects drug dosing in 3 ways: Patient susceptibility: Patients with renal impairment may be more vulnerable to a specific drug effect. Pharmacodynamic change: The effect of a drug may be increased or decreased in patients with renal disease.
15 maj 2007 · Article Sections. Chronic kidney disease affects renal drug elimination and other pharmacokinetic processes involved in drug disposition (e.g., absorption, drug distribution, nonrenal...
For drugs that are excreted by the kidney, the main concern is that there could be a prolongation of their t½ and significant drug accumulation. Clinically, this often means that single doses or loading doses of a drug are often the same as for individuals with normal renal function.
1 paź 2019 · If the dosage is not appropriately decreased in a patient with chronic kidney disease, drug concentrations can increase, risking adverse drug reactions. On the other hand, unnecessary decreases in dosage may result in undertreatment, or changing to an alternate drug with a narrower therapeutic index, lower efficacy or both.
26 lis 2021 · There is a wide range of side effects due to the multiple mechanisms of injury that drugs can have on the kidney. These side effects vary in severity [ 2 ]. Specifically, the incidence of drug-induced acute kidney injury (AKI) is 60% [ 3 ].
Drug dosage adjustment for patients with acute or chronic kidney disease is an accepted standard of practice. The challenge is how to accurately estimate a patient’s kidney function in both acute and chronic kidney disease and determine the influence of renal replacement therapies on drug disposition.
