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1. www.nature.com › articles › srep20488Cross Reactive Material 197 glycoconjugate vaccines contain ... -...

   www.nature.com › articles › srep20488

   4 lut 2016 · One of the most widely used and highly effective carrier protein is Cross-Reactive-Material-197 (CRM 197), a mutant version of the diphtheria toxin, where the single amino acid exchange of...

2. www.sciencedirect.com › diphtheria-toxoid-crm197Diphtheria Toxoid CRM197 - an overview | ScienceDirect Topics

   www.sciencedirect.com › diphtheria-toxoid-crm197

   Cross-reacting material 197 (CRM197) is a non-toxic mutant protein obtained from Corynebacterium diphtheriae diphtheria toxin which is internalized by caveolae-mediated transcytosis after binding to its receptor (diphtheria toxin receptor, DTR) (Wang et al., 2010).

3. pubmed.ncbi.nlm.nih.gov › 21715186Biochemical and biological characteristics of cross-reacting...

   pubmed.ncbi.nlm.nih.gov › 21715186

   A non-toxic mutant of diphtheria toxin, cross-reacting material 197 (CRM (197)), is a useful carrier protein with several manufacturing and other potential advantages over toxoids.

4. www.sciencedirect.com › nursing-and-health-professions › diphtheria-toxoid-crm197Diphtheria Toxoid CRM197 - an overview | ScienceDirect Topics

   www.sciencedirect.com › nursing-and-health-professions › diphtheria-toxoid-crm197

   The C domain is mutated on its catalytic site to prevent toxicity. Diphtheria toxoid (DT), tetanus toxoid (TT), and CRM 197 have been mostly used as protein carriers in licensed vaccines. CRM 197 is an enzymatically inactive and nontoxic form of DT that contains a single amino acid substitution (G52E) [104].

5. www.ncbi.nlm.nih.gov › pmc › articlesTranscutaneous Immunization with Cross-Reacting Material CRM

   www.ncbi.nlm.nih.gov › pmc › articles

   28 sty 2008 · A mucosal vaccine against diphtheria: formulation of cross reacting material (CRM 197) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery.

6. www.sciencedirect.com › science › articleReview - ScienceDirect

   www.sciencedirect.com › science › article

   1 lip 2011 · The interaction of diphtheria toxin and CRM 197 with liposomes has been studied by turbidity measurement and hydrophobic photolabeling with photo-activatable phosphatidyl cholines.

7. journals.asm.org › doi › 10Corynebacterium diphtheriae: Diphtheria Toxin, the tox Operon,...

   journals.asm.org › doi › 10

   • Zapisane w pamięci cache

   5 lip 2019 · These milestone studies of toxigenic Corynebacterium diphtheriae along with its primary virulence determinant, diphtheria toxin, have established the paradigm for the study of other related bacterial protein toxins.