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1. www.nature.com › articles › srep20488Cross Reactive Material 197 glycoconjugate vaccines contain ... -...

   www.nature.com › articles › srep20488

   4 lut 2016 · One of the most widely used and highly effective carrier protein is Cross-Reactive-Material-197 (CRM 197), a mutant version of the diphtheria toxin, where the single amino acid exchange of...

2. listlabs.com › products › bacterial-toxinsDiphtheria Toxin and CRM | Products - List Labs

   listlabs.com › products › bacterial-toxins

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   17 paź 2019 · Diphtheria toxin CRM Mutant (CRM 197) is a non-toxic, cross reactive DT mutant containing a lesion in the A chain blocking ADP-ribosylation. CRM results from a single base change in the structural gene resulting in the substitution of glutamic acid for glycine.

3. link.springer.com › article › 10Expression, Sarkosyl Solubilization, DNase Activity,...

   link.springer.com › article › 10

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   6 sie 2024 · CRM197EK is a derivative of diphtheria toxoid cross-reactive material-197 (CRM197) with two-point mutations (K51E and E148K) to improve its properties for a vaccine conjugate and drug delivery.

4. journals.asm.org › doi › 10Needle-Free Dermal Delivery of a Diphtheria Toxin CRM 197 Mutant...

   journals.asm.org › doi › 10

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   28 kwi 2015 · To provide a simple, needle-free, and broad-spectrum protein antigen delivery platform, we developed novel potassium-doped hydroxyapatite (K-Hap) microparticles with improved protein loading capabilities that can provide sustained local antigen presentation and release.

5. www.sciencedirect.com › science › articleBiochemical and biological characteristics of cross-reacting...

   www.sciencedirect.com › science › article

   1 lip 2011 · Cross-reacting material 197 is a nontoxic mutant of diphtheria toxoid with clinical applications. CRM197 is a common carrier for polysaccharide vaccines against various pathogens. This protein also has applications in cancer and other clinical settings. 1. Introduction.

6. www.ncbi.nlm.nih.gov › pmc › articlesTranscutaneous Immunization with Cross-Reacting Material CRM

   www.ncbi.nlm.nih.gov › pmc › articles

   28 sty 2008 · We report that TCI with CRM 197 significantly boosted preexisting immune responses elicited after parenteral priming with aluminum hydroxide-adsorbed diphtheria toxoid (DTxd) vaccine.

7. www.sciencedirect.com › topics › medicine-and-dentistryDiphtheria Toxoid CRM197 - an overview | ScienceDirect Topics

   www.sciencedirect.com › topics › medicine-and-dentistry

   CRM197, a nontoxic mutation of diphtheria toxin (DT), can be taken up by BCECs via binding the receptor of the precursor of heparin-binding epidermal growth factor-like growth factor (HB-EGF), also known as the diphtheria toxin receptor (DTR) (Naglich et al., 1992). DTR is expressed on the BCECs, neurons, and glial cells.