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Early Recognition of Digoxin Toxicity May Result in Improved Treatment Outcomes 1,2 INDICATION DIGIFab is indicated for the treatment of known (or strongly suspected) life-threatening digoxin toxicity associated with ventricular arrhythmias or
8 paź 2024 · The ECG features of digoxin effect are seen with therapeutic doses of digoxin and are due to: Shortening of the atrial and ventricular refractory periods — producing a short QT interval with secondary repolarisation abnormalities affecting the ST segments, T waves and U waves. Increased vagal effects at the AV node — causing a prolonged PR interval
The use of digoxin in the setting of renal and liver dysfunction necessitates significant caution and monitoring. Secondly, digitalis toxicity may develop even within widely accepted "therapeutic” range, 0.8 - 2.0 ng/ml.
The diagnosis of digoxin toxicity is based primarily on clinical suspicion and clinical features (including ECG changes) suggestive of digoxin intoxication, and can be confirmed by assessment of serum digoxin levels.
19 sty 2023 · Digoxin kills the cells and poisons the tissues of the fetus. The kidneys excrete digoxin in direct proportion to the glomerular filtration rate; the liver metabolizes 16%. Digoxin has a half-life that varies from 36 to 48 hours, which may increase in cases of renal failure.
10 lut 2020 · Electrocardiography (ECG) is an important way to evaluate patients with cirrhosis and may reveal significant changes associated with liver disease. Our study aimed to evaluate ECG changes in patients with diagnosed liver cirrhosis and compare them to patients with chronic hepatitis.
21 sie 2023 · As digoxin is now the only cardiac glycoside available in most countries, the method of initiating therapy with digoxin for patients with atrial fibrillation is presented here. Recommendations regarding the use of digoxin in the management of heart failure or arrhythmias are discussed separately.
