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13 cze 2005 · The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.
Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. [1] It may also be used for prevention of loiasis in those at high risk. [1]
Dietylokarbamazyna (łac. diethylcarbamazinum) – wielofunkcyjny organiczny związek chemiczny, pochodna piperazyny, stosowana jako ogólnoustrojowy lek przeciwrobaczy. Mechanizm działania dietylokarbamazyny nie jest znany, wiadomo jednak, że wpływa na szlak kwasu arachidonowego [5]. Zastosowanie.
Diethylcarbamazine is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.
Diethylcarbamazine is a piperazine derivative used in the treatment of filariasis. It is microfilaricidal for W. bancrofti, B. malayi and B. timori. 6,7,75,81,82 It appears to be macrofilaricidal for these species as well (i.e. it kills adult worms) and is considered to be the drug of choice for these three infections.
diethylcarbamazine citrate diethylcarbamazine carbamazine carbilazine bitirazine caricide ethodryl notezine An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa. Molecular weight: 199.30; Formula: C10H21N3O; CLOGP: 1.62; LIPINSKI: 0; HAC: 4; HDO: 0; TPSA: 26. ...
Diethylcarbamazine is a derivative of piperazine. The mechanism of its action is not completely understood. However, it is highly likely that it causes a reduction in muscular activity, and even paralysis in helminthes.
