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17 sty 2019 · Sjögren syndrome: common ANA pattern is speckled; less commonly homogenous. Scleroderma or systemic sclerosis: ANA pattern is most commonly speckled, followed by centromeric and less commonly ...
23 lis 2020 · The highest scores for clinical relevance were obtained for the centromere (AC-3) and homogeneous (AC-1) pattern, followed by the nuclear speckled (AC-2,4,5) and cytoplasmic reticular (AC-21) patterns.
5 sty 2022 · This change results in the overarching nuclear speckled pattern (AC-4,5), classified at the competent-level to represent only the fine-speckled (AC-4) and large speckled (AC-5) patterns, both of which do not stain the mitotic condensed chromatin; this arrangement is more practical as it is consistent with the understanding that many ...
1 sie 2020 · For educational purposes and to avoid confusion, it might make sense to describe this very peculiar antibody co-presence in the “AC-5-Nuclear large/coarse speckled” pattern section of the ICAP classification tree, that now only states that the nucleoli may be stained or not stained.
Speckled AC-2, 4, 5, 29 Homogeneous AC-1 Fine speckled AC-20 Dense fine speckled AC-19 Discrete dots AC-18 Segmental AC-17 Filamentous AC-16 Linear AC-14 CENP-F AC-14 PCNA ... 4 Claessens J, Belmondo T, De Langhe E et al. Solid phase assays versus automated indirect immunofluorescence for detection of antinuclear antibodies Autoimmun Rev 2018 ...
If it's warranted, it's best to have a specialist order tests based on your symptoms. But luckily Hashimotos is a fairly easy one to test for and is a bit of an outlier from other autoimmune conditions - a TPO antibody test is the most common for diagnosing Hashimotos. You can also test for thyroglobulin antibodies.
In the ICAP Note #2, AC-4 can be further divided into fine speckled with myriad discrete tiny dots (AC-4a), or simple fine speckled (AC-4b). These are defined patterns and have respective antibody targets, immunological associations, and clinical relevance.
