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Synopsis. Dapsone is occasionally used in the treatment of the autoimmune bullous diseases, a group of disorders resulting from autoimmunity directed against basement membrane and/or intercellular adhesion molecules on cutaneous and mucosal surfaces. This review will summarize the limited published data evaluating dapsone as a therapy for the AIBD.
Although high-dose corticosteroids form the mainstay of management, there are no clinical trials regarding the effective dose. Prednisone (40-60 mg or 1 mg/kg per day) and parenteral steroids such as intravenous (IV) methylprednisolone, with most regimens using 1 g for 3 days, are used.
22 maj 2023 · Bullous systemic lupus erythematosus (BSLE) is a rare manifestation of systemic lupus erythematosus. It has clinical and histological features that may lead to misdiagnosis and delayed treatment of this easily treatable condition.
Dapsone is used to treat cutaneous lupus erythematosus (LE), bullous LE, some forms of vasculitis, neutrophilic dermatoses and other autoimmune skin diseases. How it works. Dapsone inhibits neutrophil movement and ability to initiate inflammation. Dosing. The dose of this medicine differs for different patients and different conditions.
Furthermore, dapsone has been tested to treat bullous systemic lupus erythematosus, a rare bullous condition associated with systemic lupus erythematosus . The results showed that dapsone was effective in 90% of the cases to diminished dermal infiltration of polynuclear neutrophils, alignment of these cells at the basal membrane zone and ...
Dapsone is a highly effective treatment for BSLE; in severe or recalcitrant cases, steroids or immunosuppressants are viable alternatives. 4 Potential Competing Interests The authors report no potential competing interests.
7 paź 2021 · Dapsone is the initial treatment of choice for bullous systemic lupus erythematosus. [2, 34] The response is usually dramatic, with cessation of new blister formation within 1-2 days and rapid...
