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The largest was a population-based study in ten areas of the USA, with 3010 bladder cases and 5783 controls. The relative risk for bladder cancer associated with use of artificial sweeteners was 1.0 (95% confidence interval, 0.89–1.1) among men and 1.1 (0.89–1.3) among women.
Regulators weigh in favorably about cyclamate. Use is approved in more than 100 countries, including Europe, Mexico, Australia. The conclusion that cyclamate can be safely consumed has been reached by an increasing number of governments throughout the world.
1 sty 2000 · Benign neoplasms were found during necropsy of two females in the 100 mg/kg cyclamate group and one in the 500 mg/kg group; one was an adenoma of the thyroid (791J) (Table 1) and two were leiomyomas of the uterus (772J and 801J) (Tables 1 and 2). No neoplasms were detected in the control animals.
Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
15 lut 2019 · Cyclamate is an artificial sweetener which may be harmful to human health. Cyclamate may have carcinogenic tendencies. Cyclamate is chemically produced, and its components may cause some side effects.
Among the tea-drinkers (98 cases and 281 controls), eight patients and 20 controls reported use of cyclamate, yielding a crude odds ratio of 1.2 (95% CI, 0.5–2.7). The groups of tea-drinkers and coffee-drinkers were mutually exclusive.
Whether cyclamate has adverse side effects on humans is controversial. Some studies have suggested that very high doses of cyclamate may be associated with bladder cancer or testicular atrophy in some animals, and the U.S. Food and Drug Administration has banned cyclamate from food products.
