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Several low-calorie synthetic sweeteners have recently emerged in the pharmaceutical and food industries, but their health risks due to their side effects restrict their adoption [4,5]. Several previous studies have shown that the use of artificial sweeteners can be hazardous to human health [6,7].
- Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in ...
Cyclamate thus appears to be readily absorbed by rabbits but...
- Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in ...
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
Cyclamate thus appears to be readily absorbed by rabbits but less readily by guinea-pigs and rats (Renwick & Williams, 1972a). When given to lactating dogs and rats, calcium cyclamate reached higher concentrations in the milk than in the blood (Sonders & Wiegand, 1968; Ward & Zeman, 1971).
The effects of acute, subacute and chronic administration of sodium cyclamate, sodium saccharin or combinations of cyclamate and saccharin have been studied in mice, rats and dogs. The acute toxicity of the materials was shown to vary with the strain of animal and the fat content of the diet.
1 sty 2000 · A group of 16 control animals (eight cynomolgus, [five males and three females] and eight rhesus monkeys [six males and two females]) received the vitamin sandwiches without sodium cyclamate. The monkeys were evaluated daily and weighed once a week.
10 sty 2024 · Veterinarians, who told us about the nutritional requirements of our pooches and warned us about the health concerns linked to harmful ingredients in dog food. Chemists, who explained to us how to recognize the compounds in dog food that may otherwise slip our attention.
