Search results
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
No previous study has described the effects of chronic consumption of the cyclamate and saccharin combination on oxidative stress, lipid profile, glycemic control, creatinine, and alanine transaminase activity in healthy individuals and in patients with type 2 diabetes mellitus (T2DM).
27 lis 2017 · Background. Description of the condition. Diabetes mellitus is a metabolic disorder impeding the pancreas from producing enough insulin, body cells from responding properly to the insulin produced, or both. This leads to chronic hyperglycaemia (i.e. elevated plasma glucose levels) and disturbances of carbohydrate, fat, and protein metabolism.
In Denmark, the relative risk for people of the two sexes combined was 0.78 (0.58–1.05) 14. In a study in the USA of bladder cancer in women aged 20–49, the odds ratio for regular use of artificially sweetened beverages, table-top sweetener or both was 1.1 (0.7–1.7) 15.
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
The mean intake (expressed as percentage of the ADI of 11 mg/kg bw) of cyclamates was 23% by all consumers 12–39 years of age (men, 27%; women, 21%), 34% by all consumers 12–17 years of age, 20% by all consumers 18–24 years of age and 20% by all consumers 25–39 years of age (National Food Authority, 1995).
