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Sodium cyclamate was tested for carcinogenicity both alone and in combination with other chemicals in different animal species and by several routes of administration. Following its oral administration to two strains of mice, an increased incidence of lymphosarcomas was observed in female mice of one strain; a few bladder tumours were seen in ...
Cyclamate is an artificial sweetener. It is 30–50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners. It is often used with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both ...
In cultured bladders from young female Fischer 344 rats, 12 or 24 mmol/L sodium cyclamate produced pronounced urethelial hyperplasia and dysplasia, as confirmed by histology (Knowles et al., 1986).
The continued acceptance of cyclamates outside the United States paints a fascinating picture of the subjectivity of risk, the complexity of public health decisions, and the varying shades of gray that color the landscape of global food regulation.
However, the global market for artificial sweeteners has decreased considerably over the past 10 years due to their possible harmful effects on human health, for example, cancer (Weihrauch and Diehl, 2004), obesity (Yang, 2010), and diabetes (Brown et al., 2010). In this sense, natural sweeteners like steviol glycosides (SGs) have gained ...
Whether cyclamate has adverse side effects on humans is controversial. Some studies have suggested that very high doses of cyclamate may be associated with bladder cancer or testicular atrophy in some animals, and the U.S. Food and Drug Administration has banned cyclamate from food products.
Cyclamate, odorless white crystalline powder that is used as a nonnutritive sweetener. The name usually denotes either calcium cyclamate or sodium cyclamate. Although they commonly are used as sweeteners in foods and beverages, cyclamates are banned in some places because of safety concerns.
