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CRP and ESR are among the most widely used diagnostic tests in detecting inflammatory conditions that may be caused by infection, autoimmune disorders, malignancies, or tissue necrosis. 1 The CRP test measures the level of a plasma protein (C-reactive protein) produced by liver cells in response to acute inflammation or infection. Unlike CRP ...
CRP is defined as a pentameric protein comprised of five identical, non-covalently linked 23-KD subunits arranged in cyclic symmetry in a single plane. It is a component of the innate immune response and has both pro-inflammatory and anti-inflammatory actions.
Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice. Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults.
Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are markers of inflammatory conditions and have been used extensively by clinicians both in outpatient and inpatient settings. It is important to understand the physiologic principles behind these two tests so clinicians may use them ….
Objective: A thorough understanding of the similarities and differences between these two serological markers, including factors that affect measurements, is necessary for the proper utilization and interpretation of ESR and CRP.
The distribution plot of CRP results showed a left skew with mode at about 2mg/l, whereas the equivalent ESR distribution shows a broad plateau with less skew.
ESR - Tidbits • Women generally have slightly higher ESRs then Men • ESRs rise with age: ESR < Age/2 (+5 in women) • ESRs can be affected by room temperature and laboratory technique • Although ESRs are non-specific….. – ESRs part of diagnostic criteria for Polymyalgia Rheumatica & Giant Cell Arteritis
