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22 lut 2023 · Vancomycin Levels with InsightRX. Initial: A single level should be drawn within the first 24-48 hours after the first dose. An earlier initial level may be helpful in ensuring therapeutic concentrations in certain clinical scenarios (i.e. critically ill patients, patients with high or low BMI, etc.)
Only three CPGs (ALB, BAT and WOR) recommended that vancomycin trough concentrations should be more than 5 µg/mL, and most CPGs recommended that vancomycin trough concentrations should be maintained above 10 µg/mL to avoid development of drug resistance.
7 paź 2024 · The Infectious Disease Society of America guidelines recommend vancomycin trough levels of 15–20 mg/L for severe methicillin-resistant Staphylococcus aureus. However, recent consensus guidelines of four infectious disease organizations no longer recommend vancomycin dosing using minimum serum trough concentrations.
PMID: 36271558. DOI: 10.1016/j.biopha.2022.113777. Abstract. Background: The revised vancomycin guidelines recommend replacing trough-only with trough or peak/trough Bayesian and first-order equations monitoring, citing their better AUC predictions and poor AUC-trough R 2.
1 sie 2009 · Trough serum vancomycin concentrations are the most accurate and practical method of monitoring the effectiveness of vancomycin. Trough serum concentrations should be obtained just before the fourth dose, at steady-state conditions.
6 lut 2021 · This systematic review and meta-analysis identified trough concentrations and AUC values of VCM associated with its effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed higher potential to reduce the incidence of VCM-induced AKI.
19 gru 2017 · The current vancomycin therapeutic guidelines recommend empiric doses of 15–20 mg/kg administered by intermittent infusion every 8–12 h in patients with normal kidney function. Additionally, the guidelines recommend trough concentration of 15–20 mg/L as a therapeutic goal for adult patients with severe infections.
