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1 cze 2024 · Alterations in microRNA expression by radon in human bronchial epithelial cells are mainly up-regulation of miR-15, miR-16, miR-19, miR-23, miR-125 and down-regulation of let-7, miR-124, miR-146, miR-194, miR-369, miR-373, miR-652 (Bersimbaev et al., 2020). These alterations lead to altered DNA methylation, cell cycle, oxidative stress ...
5 lip 2013 · Ionizing radiation emitted during the radioactive decay of radon and its progeny can induce a variety of cytogenetic effects that can be biologically damaging and result in an increased risk of carcinogenesis.
The exposure of cells to densely ionizing radiation, such as radon alpha particles, can initiate a series of molecular and cellular events that culminates in the development of lung and other cancers (Hall 1994).
1 sty 1984 · The valence electrons are not bound as strongly as are those of the lighter Group VIII elements, and at high radon concentrations, the energy liberated by α decay facilitates compound formation. Radon reacts with fluorine gas at 400°C to form a stable, nonvolatile fluorine compound.
5 lip 2013 · Suggested effects produced as a result of alpha particle exposure from radon include mutations, chromosome aberrations, generation of reactive oxygen species, modification of the cell cycle, up or down regulation of cytokines and the increased production of proteins associated with cell-cycle regulation and carcinogenesis.
14 gru 2020 · Radon probably influences the neuroendocrine system, affecting the adrenal glands via the pituitary gland. Subsequent hormonal changes modulate T-cell function. Radon water therapy is recognized primarily by dermatologists and rheumatologists.
27 kwi 2023 · In the following paragraphs, various irradiation methods enabling exposure of cells to radon and its progeny are described, together with the dosimetry as well as the main radiobiological findings.
