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13 mar 2023 · The decision to treat cold urticaria syndromes depends primarily on the underlying etiology, severity of response to cold stimulus, and how greatly it affects quality of life, including the frequency of anticipated cold exposure.
Our systematic review included 16 studies, 9 of which met the eligibility criteria for the meta-analysis. We analyzed the effects of treatments on critical temperature thresholds (CTTs) and critical stimulation time thresholds (CSTTs), as well as on rates of complete response and adverse events.
High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study.
The treatment of choice for csU is a second-generation H1 antihistamine. Higher doses, up to a maximum of four times the standard dose, are often more effective but are off-label use and are not tolerated by all patients.
Cold urticaria is a subtype of chronic inducible urticaria (CIndU) associated with significant morbidity and a risk for anaphylaxis. Few studies have assessed the prevalence, management, and prevalence of associated anaphylaxis of cold urticaria.
Cold urticaria is a hypersensitivity to cold exposure (eg, wind, freezer compartments, cold water) resulting in histamine release. It usually presents as localized redness, burning, pruritus, and urticaria in the exposed areas, but may progress to a generalized systemic reaction, shock, and death.
1 mar 2022 · The next treatment depends on the type of chronic inducible urticaria, e.g. phototherapy can be considered for dermographism or ciclosporin for cold urticaria. The guideline explains treatment in pregnancy, patients who are breastfeeding and for children.
